If you travel by car in Greece it is necessary to have a green card (still obligatory in Macedonia), while an international driving license is no longer necessary for Greece or for Macedonia. It is pretty easy to reach Lefkada because the route is quite simple and the signaling is pretty good. From Belgrade to Lefkada there are about 980km, out of which there are about 770km of highway, so in case you pass the border quickly, the journey takes about 12 hours.

For those who travel frequently, the journey from Serbia to Greece is well known. From Belgrade to Nis, from where the highway goes in the direction of Thessaloniki, there are three tolls to be paid. The first one is at the toll station in front of Nis for the section Belgrade-Nis and it costs 800 dinars, the second one is slightly ahead of Prokuplje, near the village of Doljevac, for the section Nis-Presevo and you should pay 210 dinars, and the third one is at the Presevo toll station and it costs 80 dinars. Here the main road continues to Vranje, passes by the motel Predejane, through the Grdelic gorge towards Bujanovac and Presevo to the border crossing Bogorodica. For those traveling from Subotica, should be added another 320 dinars for the section Belgrade-Subotica to the total price of tolls, which is 1090 dinars.

In order to enter Macedonia, it is necessary to have an international car insurance card (green card) and an authorization to drive a motor vehicle, in case you do not use your own car for a trip. Through Macedonia the road is quite simple, from the border crossing next to Kumanovo to Skopje and further right to the south. In Macedonia this road leads through three toll stations. On the first one, 16km after the border, the toll is 60 denars or 1.5e (you should have at least 50 cents in coins), on the other one in front of Veles 80 denars or 2e and another 60 denars, or 1.5e, at the third toll station just before the exclusion for Prilep. The road leads to the border crossing Bogorodica-Evzoni. After crossing the border, the motorway (E75 / 1) is heading towards Athens. At about 500m from the pass there is a new toll station where the toll is 1.80e. In addition to the standard equipment, no green card is required for entry, but for driving through Greece, it is necessary to have fire extinguisher and spare eyeglasses or lenses for those who need to use them in the ride.

After leaving the highway, the ride continues in the direction of Thessaloniki. At the first exclusion of Thessaloniki and Edessa, you should continue right and 60 km after the border, at the first intersection, turn right and follow the newly built and very interesting highway (E90 / A2) which, along with 49 tunnels, leads to Lefkada near the town of Veria. Shortly after, at place called Nea Malgara, you will see the first toll station in Greece where the toll should be paid 2.4e. There are three toll stations on the way to Lefkada, and at each one the price is the same. The second toll station is located in the city of Polimilos, after Veria on the road to Kozani, 135km from the Macedonian-Greek border, while the third one is at Malakasi on the road to Ioannina, at 242km from the border and just outside the town of Metsovo.

After about 850km from Belgrade, the next important crossroad is near Ioannina, from where you should turn right to the main road (E951) in the direction of Preveza towards the town of Arta. Just before turning to Arta on the right continues the road 21 which leads to Preveza, by the sea, through the city of Kanali. Just before turning to Preveza, you should enter the road (E952) which leads right through the underwater tunnel, after which the first toll station is reached in this part where the toll is 3e. The first next sign of recognition is the airport, from where the route continues to the place of Agios Nikolaos, where you should turn right to the section marked 42. A dozen kilometers from here comes the bridge that represents the entrance to the island of Lefkada and to the capital Lefkas. This bridge is mobile, connects an island with the continental part of Greece and rises every hour for yachts, boats and ships. The bridge makes the travelling by car easier and thanks to it Lefkada is the only island in Greece that can be reached by the road, without using a ferry.

About 50km shorter and slightly cheaper road is possible through Bitola, which after the border, at the crossing of Metzitili, leads right to Kozani, from where you should turn right for Ioannina. Regardless of mileage, this road is significantly slower, as compared to the first one there is a 150km shorter highway, so it extends the journey in about an hour.